UPSC Key for July 29, 2026 Covers Cauvery Water Dispute SHetA2 Therapy
GS3Economy · S&T · Environment · Security· Biotechnology & health research· Prelims + Mains·
Why in news
ICMR's National Institute of Cancer Prevention and Research has developed SHetA2, a small molecule oral therapy to treat cervical cancer by targeting HPV-related proteins.
Background
SHetA2 is a chemically manufactured, low-weight small molecule therapy designed to stop Human Papillomavirus (HPV) from causing cancer. It targets three specific proteins: mortalin, heat shock cognate (hsc70), and glucose regulated protein 78 (Grp78) to destroy the harmful E7 protein.
Facts for Prelims
- S&TSHetA2: A small molecule therapy targeting HPV-E7 protein connection.
- S&TICMR-NICPR: The body responsible for the development of the SHetA2 therapy.
- FactCervical cancer is primarily caused by the Human Papillomavirus (HPV) infection.
- S&TSmall molecule therapies: Chemically manufactured, low-weight compounds easily absorbed by the body.
For Mains
Q. Discuss the significance of small molecule therapies like SHetA2 in addressing the burden of cervical cancer in India and their role in achieving Universal Health Coverage.
Dimensions to cover in your answer
- burden of cervical cancer in India
- cost-effectiveness of small molecule therapies
- role of ICMR in indigenous R&D
- public health infrastructure for cancer screening
Keywords: Small molecule therapy · HPV · Cervical Cancer · ICMR · Biotechnology · Public Health
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